Metformin has been used for over 60 years to manage type 2 diabetes, but recent research suggests it may contain anti-aging properties. Several studies have shown that metformin reduced the incidence of multiple age-related diseases and all-cause mortality.
BENEFITS OF METFORMIN IN RELATION TO AGING INCLUDE:
- Decreased inflammation: Metformin has been shown to reduce inflammation in the body, which may help to prevent many age-related diseases.
- Increased insulin sensitivity: Insulin resistance is a significant factor in the development of many age-related chronic diseases such as heart disease, stroke, and Alzheimer’s disease. Metformin has the ability to lower blood sugar levels and increase insulin sensitivity.
- Increased autophagy: As we age, the process of autophagy, which helps to remove damaged cells from the body, slows down. Metformin is able to induce autophagy and enhance the body’s ability to eliminate and or transform damaged cells
- Increased NAD+: NAD+ is a coenzyme found in all living cells that has a crucial role in various cellular processes, including metabolism, DNA repair, and energy production. Over time, your NAD+ levels decline, leading to age-related decline in cellular function. Metformin can increase NAD+ levels by inhibiting an enzyme that breaks down NAD+, and as a result, increase the cells’ ability to utilize NAD+.
It is important to consult a healthcare professional prior to taking metformin. The potential side effects of metformin are generally mild and limited to gastrointestinal distress, such as indigestion, abdominal pain, diarrhea, and gas. The ability of metformin to reduce early mortality associated with various diseases, including diabetes, cardiovascular disease, cancer, and cognitive decline, can extend your period of life spent in good health.